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【學術演講】2017/12/04 (一) 12:10 潘文驥老師 ─ Traffic Exposure and Cardiovascular Risks in REVEAL-HBV
時間:106年12月04日 (一) 12:10 – 13:00
地點:醫學二館221室

主講人:潘文驥老師(本校環衛所助理教授)

 

Topic : Traffic Exposure and Cardiovascular Risks in REVEAL-HBV

 

Background/Aim

Epidemiological evidence shows that exposure to traffic-related pollution is positively associated with cardiovascular diseases (CVD). However, little is known about how traffic exhaust generated by different sources (e.g. motorcycles, gasoline-powered cars, diesel-engine vehicles) affect CVD. Therefore we aimed to assess the association between exposure to different sources of traffic exhaust and CVD mortality.

 

Methods

We included 9,917 eligible participants from REVEAL-HBV (Risk Evaluation of Viral-load Elevation and Associated Liver Cancer-Hepatitis B Virus), a community-based cohort study established in 1991 in Taiwan. The ascertainment of CVD death was based Taiwan Death Certificate (ICD-9: 400 to 440). Participants’ residential exposure to traffic vehicles exhaust from different sources (i.e. motorcycles, small cars, buses, and diesel-engine trucks) was retrieved from Directorate General of Highways (Ministry of Transportation and Communication, Taiwan) from 2005 to 2014. Cox proportional hazards models were applied to evaluate the association between traffic volume exposure and CVD mortality, adjusting for age, sex, BMI, smoking, alcohol consumption, and proximity to the major roadway.

 

Results

A total of 844 CVD mortality was identified (1991- 2014) with a median follow-up time of 22.8 years. We found that CVD mortality was increased by 19.0% with one unit increment on trucks in logarithm scale (adjusted hazard ratio [aHR] =1.19; 95% confidence intervals [CI] =1.01 to 1.40; p-value=0.042), whereas other types of vehicle exposure showed positive but statistically insignificant associations. Relationship between trucks exposure and CVD mortality remained positive with further adjustment for co-exposure of other traffic vehicles (aHR=1.05; 95%CI=1.01 to 1.11) using ridge regression.

 

Conclusions

In this prospective cohort study, we found evidence suggests that long-term exposure to truck exhaust is positively associated with CVD mortality in a Taiwanese cohort study.

 

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